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Bioluminescent Bioreporter Integrated Circuits (BBICs): Whole-Cell Environmental Monitoring Devices
1
Technical Paper
1999-01-2152
ISSN: 0148-7191, e-ISSN: 2688-3627
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Language:
English
Abstract
We report a chemical sensing technology composed of engineered bioluminescent bacteria placed on an integrated microluminometer. The bacteria have been engineered to luminesce when the targeted compound is metabolized, while the microluminometer detects, processes, and then reports the magnitude of this optical signal. In this work we report our progress in the development of these biosensors and present data from our early prototypes.
Authors
- Michael L. Simpson - Oak Ridge National Laboratory
- Michael J. Paulus - Oak Ridge National Laboratory
- Gerald E. Jellison - Oak Ridge National Laboratory
- Gary S. Sayler - University of Tennessee Center for Environmental Biotechnology
- Bruce M. Applegate - University of Tennessee Center for Environmental Biotechnology
- Steven Ripp - University of Tennessee Center for Environmental Biotechnology
- David E. Nivens - University of Tennessee Center for Environmental Biotechnology
Citation
Simpson, M., Paulus, M., Jellison, G., Sayler, G. et al., "Bioluminescent Bioreporter Integrated Circuits (BBICs): Whole-Cell Environmental Monitoring DevicesAlso In
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